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EIF4A2 Antibody

Product Specifications

Background

Eukaryotic initiation factor 4A plays an important role in the binding of mRNA to the 43S preinitiation complex when protein synthesis begins. Two highly homologous forms of functional EIF4A genes, Eif4a1 and Eif4a2, have been isolated in mice; yeast cells also possess 2 EIF4A genes, TIF1 and TIF2. The murine Eif4a and yeast TIF genes appear to belong to a DEAD-box gene family, whose members exhibit extensive amino acid similarity and contain the asp-glu-ala-asp (DEAD) sequence. DEAD-box genes have been identified in species ranging from E-coli to humans. Their function appears to be related to transcriptional/translational regulation (referenced from OMIM) .

NCBI Gene ID

1974

Swiss Prot

Q14240

Accession Number

Q14240

Host

Rabbit

Reactivity

Human

Immunogen

This EIF4A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 333-360 amino acids from the C-terminal region of human EIF4A2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Mouse, Rabbit, Chicken, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=63-830

Calculated Molecular Weight

46 kDa

Fragment

Rabbit Ig

Symbol

EIF4A2

NCBI Official Name

Eukaryotic initiation factor 4A-II

NCBI Organism

Homo sapiens

Background Reference 01

Martins-de-Souza, D., et.al., Neural Transm 116 (3), 275-289 (2009)

Background Reference 02

Lin, C.J., et.al., Cancer Res. 68 (13), 5326-5334 (2008)

Other Product Names

Eukaryotic initiation factor 4A-II, eIF-4A-II, eIF4A-II, ATP-dependent RNA helicase eIF4A-2, EIF4A2, DDX2B, EIF4F

Tested Applications

WB, IHC-P, Flow

Protein ID

45645183

Physical Properties

Liquid

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