MUTYH Antibody
Product Specifications
Background
MYH is the eukaryotic homolog to the E. coli protein MutY. It was first identified in HeLa cells and nicks DNA replication errors, specifically A/G mismatches. MYH is involved in oxidative DNA damage repair. It initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. It possesses both adenine and 2-OH-A DNA glycosylase activities.
NCBI Gene ID
4595
Swiss Prot
Q9UIF7
Accession Number
Q9UIF7
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This MUTYH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-367 amino acids from the Central region of human MUTYH.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
60 kDa
Fragment
Rabbit Ig
Symbol
MUTYH
NCBI Official Name
A/G-specific adenine DNA glycosylase
NCBI Organism
Homo sapiens
Background Reference 01
Kim C.J., et.al., Oncogene 23:6820-6822 (2004) .
Background Reference 02
Isidro G., et.al., Hum. Mutat. 24:353-354 (2004) .
Background Reference 03
Sieber O.M., et.al., N. Engl. J. Med. 348:791-799 (2003) .
Other Product Names
A/G-specific adenine DNA glycosylase, 322-, MutY homolog, hMYH, MUTYH, MYH
Tested Applications
WB, IF, Flow
Protein ID
48428272
Physical Properties
Liquid
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