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CIRBP Antibody

Product Specifications

Background

CIRBP is cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. It acts as a translational activator and seems to play an essential role in cold-induced suppression of cell proliferation. It binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. This protein acts as a translational repressor (By similarity) and promotes assembly of stress granules (SGs), when overexpressed.

NCBI Gene ID

1153

Swiss Prot

Q14011

Accession Number

Q14011

Host

Rabbit

Reactivity

Human

Immunogen

This CIRBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-172 amino acids from the C-terminal region of human CIRBP.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat, Hamster

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=63-800

Calculated Molecular Weight

19 kDa

Fragment

Rabbit Ig

Symbol

CIRBP

NCBI Official Name

Cold-inducible RNA-binding protein

NCBI Organism

Homo sapiens

Background Reference 01

Colinge J., et.al., Submitted (OCT-2008) to UniProtKB.

Background Reference 02

Yang R., et.al., Nucleic Acids Res. 34:1224-1236 (2006) .

Other Product Names

Cold-inducible RNA-binding protein, A18 hnRNP, Glycine-rich RNA-binding protein CIRP, CIRBP, A18HNRNP, CIRP

Tested Applications

WB, IHC-P

Protein ID

5921786

Physical Properties

Liquid

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