IL10 Antibody
Product Specifications
Background
The protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
NCBI Gene ID
3586
Swiss Prot
P22301
Accession Number
P22301
Host
Rabbit
Reactivity
Human
Immunogen
This IL10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-53 amino acids from the Central region of human IL10.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
21 kDa
Fragment
Rabbit Ig
Symbol
IL10
NCBI Official Name
Interleukin-10
NCBI Organism
Homo sapiens
Background Reference 01
Trajkov, D., et.al., IndianTuberc 56 (3), 117-131 (2009)
Background Reference 02
Kim, J.M., et.al., J. Immunol. 148 (11), 3618-3623 (1992)
Other Product Names
Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF, IL10
Tested Applications
WB, IHC-P, Flow
Protein ID
124292
Physical Properties
Liquid
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