CFB Antibody
Product Specifications
Background
CFB encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation.
NCBI Gene ID
629
Swiss Prot
P00751
Accession Number
P00751
Host
Rabbit
Reactivity
Human
Immunogen
This CFB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 469-494 amino acids from the Central region of human CFB.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=63-753
Calculated Molecular Weight
86 kDa
Fragment
Rabbit Ig
Symbol
CFB
NCBI Official Name
Complement factor B
NCBI Organism
Homo sapiens
Background Reference 01
Munch, I.C., et.al., Invest. Ophthalmol. Vis. Sci. (2009) In press.
Background Reference 02
Gateva, V., et.al., Nat. Genet. 41 (11), 1228-1233 (2009) .
Other Product Names
Complement factor B, C3/C5 convertase, Glycine-rich beta glycoprotein, GBG, PBF2, Properdin factor B, Complement factor B Ba fragment, Complement factor B Bb fragment, CFB, BF, BFD
Tested Applications
WB, IHC-P, Flow
Protein ID
584908
Physical Properties
Liquid
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