HLA-G Antibody
Product Specifications
Background
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin) . The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail.
NCBI Gene ID
3135
Swiss Prot
P17693
Accession Number
P17693
Host
Rabbit
Reactivity
Human
Immunogen
This HLA-G antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-89 amino acids from the Central region of human HLA-G.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
38 kDa
Fragment
Rabbit Ig
Symbol
HLA-G
NCBI Official Name
HLA class I histocompatibility antigen, alpha chain G
NCBI Organism
Homo sapiens
Background Reference 01
Walpole, N.G., et.al., J. Mol. Biol. 397 (2), 467-480 (2010)
Background Reference 02
Tian, W., et.sl., Tissue Antigens 75 (3), 227-234 (2010)
Other Product Names
HLA class I histocompatibility antigen, alpha chain G, HLA G antigen, MHC class I antigen G, HLA-G, HLA-60, HLAG
Tested Applications
WB, IHC-P, Flow
Protein ID
122132
Physical Properties
Liquid
Curated Selection
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