AIFM1 Antibody
Product Specifications
Background
AIFM1 is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this protein induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9.
NCBI Gene ID
9131
Swiss Prot
O95831
Accession Number
O95831
Host
Rabbit
Reactivity
Human
Immunogen
This AIFM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-98 amino acids from the N-terminal region of human AIFM1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Immunology, Obesity, Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
67 kDa
Fragment
Rabbit Ig
Symbol
AIFM1
NCBI Official Name
Apoptosis-inducing factor 1, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
References for protein:
Background Reference 02
Daugas, E., et.al., FASEB J. 14 (5), 729-739 (2000)
Background Reference 03
Schulthess, F.T., et.al., PLoS ONE (2), E4394 (2009)
Background Reference 04
References for U251 cell line:
Other Product Names
Apoptosis-inducing factor 1, mitochondrial, 111-, Programmed cell death protein 8, AIFM1, AIF, PDCD8
Tested Applications
WB, IHC-P, IF, Flow
Physical Properties
Liquid
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