SCNN1A Antibody

Product Specifications

Background

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been sociated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids.

NCBI Gene ID

6337

Swiss Prot

P37088

Accession Number

P37088

Host

Rabbit

Reactivity

Human

Immunogen

This SCNN1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 365-391 amino acids from the Central region of human SCNN1A.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

76 kDa

Fragment

Rabbit Ig

Symbol

SCNN1A

NCBI Official Name

Amiloride-sensitive sodium channel subunit alpha

NCBI Organism

Homo sapiens

Background Reference 01

Azad A.K., et.al., Hum. Mutat. 30:1093-1103 (2009) .

Other Product Names

Amiloride-sensitive sodium channel subunit alpha, Alpha-NaCH, Epithelial Na (+) channel subunit alpha, Alpha-ENaC, ENaCA, Nonvoltage-gated sodium channel 1 subunit alpha, SCNEA, SCNN1A, SCNN1