CYP8B1 Antibody
Product Specifications
Background
CYP8B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless.
NCBI Gene ID
1582
Swiss Prot
Q9UNU6
Accession Number
Q9UNU6
Host
Rabbit
Reactivity
Human
Immunogen
This CYP8B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 471-501 amino acids from the C-terminal region of human CYP8B1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=63-644
Calculated Molecular Weight
58 kDa
Fragment
Rabbit Ig
Symbol
CYP8B1
NCBI Official Name
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
NCBI Organism
Homo sapiens
Background Reference 01
Zhang, M. et.al., J. Biol. Chem. 276 (45), 41690-41699 (2001)
Background Reference 02
Wang, J., et.al., Histochem. Cell Biol. 123 (4-5), 441-446 (2005)
Other Product Names
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase, 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase, CYPVIIIB1, Cytochrome P450 8B1, Sterol 12-alpha-hydroxylase, CYP8B1, CYP12
Tested Applications
WB, IHC-P, Flow
Protein ID
308153428
Physical Properties
Liquid
Curated Selection
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