FLCN Antibody
Product Specifications
Background
FLCN may play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas) . FLCN may be a tumor suppressor. May be involved in colorectal tumorigenesis. It may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways.
NCBI Gene ID
201163
Swiss Prot
Q8NFG4
Accession Number
Q8NFG4
Host
Rabbit
Reactivity
Human
Immunogen
This FLCN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325-354 amino acids from the Central region of human FLCN.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
64 kDa
Fragment
Rabbit Ig
Symbol
FLCN
NCBI Official Name
Folliculin
NCBI Organism
Homo sapiens
Background Reference 01
Khoo, S.K., et.al., J. Med. Genet. 39 (12), 906-912 (2002)
Background Reference 02
Shin, J.H., et.al., J. Med. Genet. 40 (5), 364-367 (2003)
Other Product Names
Folliculin, BHD skin lesion fibrofolliculoma protein, Birt-Hogg-Dube syndrome protein, FLCN, BHD
Tested Applications
WB, IHC-P
Protein ID
74751276
Physical Properties
Liquid
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