CYP24A1 Antibody

Product Specifications

Background

CYP24A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system.

NCBI Gene ID

1591

Swiss Prot

Q07973

Accession Number

Q07973

Host

Rabbit

Reactivity

Human

Immunogen

This CYP24A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 466-494 amino acids from the C-terminal region of human CYP24A1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

59 kDa

Fragment

Rabbit Ig

Symbol

CYP24A1

NCBI Official Name

1,25-dihydroxyvitamin D (3) 24-hydroxylase, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Okuda, K., et.al., J. Lipid Res. 36 (8), 1641-1652 (1995)

Background Reference 02

Bosse, Y., et.al., Respir. Res. 10, 98 (2009)

Other Product Names

25-dihydroxyvitamin D (3) 24-hydroxylase, mitochondrial, 24-OHase, Vitamin D (3) 24-hydroxylase, Cytochrome P450 24A1, Cytochrome P450-CC24, CYP24A1, CYP24