RB1 Antibody
Product Specifications
Background
RB1 is a negative regulator of the cell cycle and was the first tumor suppressor gene found. This protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1.
NCBI Gene ID
5925
Swiss Prot
P06400
Accession Number
P06400
Host
Rabbit
Reactivity
Human
Immunogen
This RB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 858-886 amino acids from the C-terminal region of human RB1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
106 kDa
Fragment
Rabbit Ig
Symbol
RB1
NCBI Official Name
Retinoblastoma-associated protein
NCBI Organism
Homo sapiens
Background Reference 01
Connell-Crowley, L., et.al., Mol. Biol. Cell (2), 287-301 (1997)
Background Reference 02
Kitagawa, M., et.al., EMBO J. 15 (24), 7060-7069 (1996)
Other Product Names
Retinoblastoma-associated protein, p105-Rb, pRb, Rb, pp110, RB1
Tested Applications
WB, IHC-P, Flow
Protein ID
132164
Physical Properties
Liquid
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