IL1B Antibody
Product Specifications
Background
IL1B is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE) . This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system ( CNS) is found to contribute to inflammatory pain hypersensitivity.
NCBI Gene ID
3553
Swiss Prot
P01584
Accession Number
P01584
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This IL1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-174 amino acids from the Central region of human IL1B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology, Obesity, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rabbit, Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
31 kDa
Fragment
Rabbit Ig
Symbol
IL1B
NCBI Official Name
Interleukin-1 beta
NCBI Organism
Homo sapiens
Background Reference 01
Yu, J., et.al., Am. J. Gastroenterol. (2009)
Background Reference 02
Ito, A., et.al., J. Biol. Chem. 271 (25), 14657-14660 (1996)
Other Product Names
Interleukin-1 beta, IL-1 beta, Catabolin, IL1B, IL1F2
Tested Applications
WB, IHC-P, Flow
Protein ID
62906858
Physical Properties
Liquid
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