SLC11A1 Antibody
Product Specifications
Background
NRAMP1, also known as SLC11A1, is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as leprosy and tuberculosis, and inflammatory diseases such as Crohn disease and rheumatoid arthritis. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.
NCBI Gene ID
6556
Swiss Prot
P49279
Accession Number
P49279
Host
Rabbit
Reactivity
Human
Immunogen
This SLC11A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-276 amino acids from the Central region of human SLC11A1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
60 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SLC11A1
NCBI Official Name
Natural resistance-associated macrophage protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Jin, J., et.al., Zhongguo Dang Dai Er Ke Za Zhi 11 (4), 283-287 (2009)
Background Reference 02
Liu, J., et.al., Am. J. Hum. Genet. 56 (4), 845-853 (1995)
Other Product Names
Natural resistance-associated macrophage protein 1, NRAMP 1, Solute carrier family 11 member 1, SLC11A1, LSH, NRAMP, NRAMP1
Tested Applications
WB, IF
Protein ID
1352521
Physical Properties
Liquid
Curated Selection
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