PLA2G4A Antibody
Product Specifications
Background
PLA2G4A is a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca (2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
NCBI Gene ID
5321
Swiss Prot
P47712
Accession Number
P47712
Host
Rabbit
Reactivity
Human
Immunogen
This PLA2G4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 513-541 amino acids from the Central region of human PLA2G4A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Chicken, Zebrafish, Mouse, Rabbit, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=63-495
Calculated Molecular Weight
85 kDa
Fragment
Rabbit Ig
Symbol
PLA2G4A
NCBI Official Name
Cytosolic phospholipase A2
NCBI Organism
Homo sapiens
Background Reference 01
Sharp, J.D., et.al., J. Biol. Chem. 266 (23), 14850-14853 (1991)
Background Reference 02
Clark, J.D., et.al., Cell 65 (6), 1043-1051 (1991)
Other Product Names
Cytosolic phospholipase A2, cPLA2, Phospholipase A2 group IVA, Phospholipase A2, Phosphatidylcholine 2-acylhydrolase, Lysophospholipase, PLA2G4A, CPLA2, PLA2G4
Tested Applications
WB, IHC-P, IF, Flow
Protein ID
317373312
Physical Properties
Liquid
Curated Selection
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