PPP3CC Antibody

Product Specifications

Background

Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca (2+) -dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha, calcineurin A-beta, and calcineurin A-gamma, have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity) .

NCBI Gene ID

5533

Swiss Prot

P48454

Accession Number

P48454

Host

Rabbit

Reactivity

Human

Immunogen

This PPP3CC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 482-512 amino acids from the C-terminal region of human PPP3CC.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

58 kDa

Fragment

Rabbit Ig

Symbol

PPP3CC

NCBI Official Name

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

NCBI Organism

Homo sapiens

Background Reference 01

Eastwood, S.L., et al., Biol. Psychiatry 57 (7) :702-710 (2005) .

Background Reference 02

Gerber, D.J., et al., Proc. Natl. Acad. Sci. U.S.A. 100 (15) :8993-8998 (2003) .

Background Reference 03

Bennasser, Y., et al., Virology 303 (1) :174-180 (2002) .

Background Reference 04

Esau, C., et al., J. Exp. Med. 194 (10) :1449-1459 (2001) .

Other Product Names

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform, CAM-PRP catalytic subunit, Calcineurin, testis-specific catalytic subunit, Calmodulin-dependent calcineurin A subunit gamma isoform, PPP3CC, CALNA3, CNA3