Cdc14 Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.

NCBI Gene ID

8556

Swiss Prot

Q9UNH5

Accession Number

Q9UNH5

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This Cdc14 antibody is generated from rabbits immunized with a recombinant protein encoding aa 1~379 of human cdc14.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by dialysis against PBS

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

67 kDa

Fragment

Rabbit Ig

Symbol

CDC14A

NCBI Official Name

Dual specificity protein phosphatase CDC14A

NCBI Organism

Homo sapiens

Background Reference 01

Kaiser, B.K., et al. Mol. Biol. Cell 13 (7), 2289-2300 (2002)

Background Reference 02

Mailand, N., et al. Nat. Cell Biol. (4), 317-322 (2002)

Background Reference 03

Bembenek, J. and Yu, H. J. Biol. Chem. 276 (51), 48237-48242 (2001)

Background Reference 04

Li, L., et al. J. Biol. Chem. 275 (4), 2410-2414 (2000)

Other Product Names

Dual specificity protein phosphatase CDC14A, CDC14 cell division cycle 14 homolog A, CDC14A

Tested Applications

WB, IHC-P, Flow

Protein ID

55976620

Physical Properties

Liquid

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