PRL3 Antibody

Product Specifications

Background

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs) . PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist.

NCBI Gene ID

11156

Swiss Prot

O75365

Accession Number

O75365

Host

Rabbit

Reactivity

Human

Immunogen

This PRL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 135-164 amino acids from the C-terminal region of human PRL3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

20 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PTP4A3

NCBI Official Name

Protein tyrosine phosphatase type IVA 3

NCBI Organism

Homo sapiens

Background Reference 01

Wu, X., et al., Am. J. Pathol. 164 (6) :2039-2054 (2004) .

Background Reference 02

Kozlov, G., et al., J. Biol. Chem. 279 (12) :11882-11889 (2004) .

Background Reference 03

Bardelli, A., et al., Clin. Cancer Res. 9 (15) :5607-5615 (2003) .

Background Reference 04

Matter, W.F., et al., Biochem. Biophys. Res. Commun. 283 (5) :1061-1068 (2001) .

Other Product Names

Protein tyrosine phosphatase type IVA 3, PRL-R, Protein-tyrosine phosphatase 4a3, Protein-tyrosine phosphatase of regenerating liver 3, PRL-3, PTP4A3, PRL3