PTPIA2 beta Antibody

Product Specifications

Background

PTPIA2beta is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus.

NCBI Gene ID

5799

Swiss Prot

Q92932

Accession Number

Q92932

Host

Rabbit

Reactivity

Human

Immunogen

This PTPIA2 beta antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-125 amino acids from the N-terminal region of human PTPIA2 beta.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

111 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PTPRN2

NCBI Official Name

Receptor-type tyrosine-protein phosphatase N2

NCBI Organism

Homo sapiens

Background Reference 01

Schmidli, R.S., et al., Autoimmunity 28 (1) :15-23 (1998) .

Background Reference 02

Li, Q., et al., Proc. Assoc. Am. Physicians 109 (4) :429-439 (1997) .

Background Reference 03

Cui, L., et al., J. Biol. Chem. 271 (40) :24817-24823 (1996) .

Background Reference 04

Kawasaki, E., et al., Biochem. Biophys. Res. Commun. 227 (2) :440-447 (1996) .

Other Product Names

Receptor-type tyrosine-protein phosphatase N2, R-PTP-N2, Islet cell autoantigen-related protein, IAR, ICAAR, Phogrin, PTPRN2, KIAA0387

Tested Applications

Protein ID

116242738

Physical Properties

Liquid

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