PTP gamma Antibody

Product Specifications

Background

PTPgamma is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. The gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.

NCBI Gene ID

5793

Swiss Prot

P23470

Accession Number

P23470

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This PTP gamma antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 751-782 amino acids from the Central region of human PTP gamma.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

162 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PTPRG

NCBI Official Name

Receptor-type tyrosine-protein phosphatase gamma

NCBI Organism

Homo sapiens

Background Reference 01

Liu, S., et al., Breast Cancer Res. Treat. 71 (1) :21-35 (2002) .

Background Reference 02

Kastury, K., et al., Genomics 32 (2) :225-235 (1996) .

Background Reference 03

Barnea, G., et al., Mol. Cell. Biol. 13 (3) :1497-1506 (1993) .

Background Reference 04

LaForgia, S., et al., Proc. Natl. Acad. Sci. U.S.A. 88 (11) :5036-5040 (1991) .

Other Product Names

Receptor-type tyrosine-protein phosphatase gamma, Protein-tyrosine phosphatase gamma, R-PTP-gamma, PTPRG, PTPG

Tested Applications

Protein ID

229463033

Physical Properties

Liquid

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