TRPM8 Antibody

Product Specifications

Background

TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. It is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH and involved in menthol sensation. It is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium.

NCBI Gene ID

79054

Swiss Prot

Q7Z2W7

Accession Number

Q7Z2W7

Host

Rabbit

Reactivity

Human

Immunogen

This TRPM8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-552 amino acids from the Central region of human TRPM8.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

128 kDa

Fragment

Rabbit Ig

Symbol

TRPM8

NCBI Official Name

Transient receptor potential cation channel subfamily M member 8

NCBI Organism

Homo sapiens

Background Reference 01

Tsavaler L., Cancer Res. 61:3760-3769 (2001) .

Background Reference 02

Kiessling A., Prostate 56:270-279 (2003) .

Background Reference 03

Bodding, M., Cell Calcium 42 (6), 618-628 (2007)

Other Product Names

Transient receptor potential cation channel subfamily M member 8, Long transient receptor potential channel 6, LTrpC-6, LTrpC6, Transient receptor potential p8, Trp-p8, TRPM8, LTRPC6, TRPP8