PIK3CG Antibody

Product Specifications

Background

PIK3CG belongs to the pi3/pi4-kinase family of proteins. It is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene for this protein is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.

NCBI Gene ID

5294

Swiss Prot

P48736

Accession Number

P48736

Host

Rabbit

Reactivity

Human

Immunogen

This PIK3CG antibody is generated from rabbits immunized with human PIK3CG Recombinant Protein.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Immunology, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

126 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

PIK3CG

NCBI Official Name

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

NCBI Organism

Homo sapiens

Background Reference 01

Andreozzi, F., et al., Endocrinology 145 (6) :2845-2857 (2004) .

Background Reference 02

Reddy, S.A., et al., Biochem. Biophys. Res. Commun. 316 (4) :1022-1028 (2004) .

Background Reference 03

Osaki, M., et al., J. Cancer Res. Clin. Oncol. 130 (1) :8-14 (2004) .

Background Reference 04

Khan, N.A., et al., J. Neurovirol. 9 (6) :584-593 (2003) .

Other Product Names

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, PI3-kinase subunit gamma, PI3K-gamma, PI3Kgamma, PtdIns-3-kinase subunit gamma, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma, PtdIns-3-kinase subunit p110-gamma, p110gamma, Phosphoinositide-3-kinase catalytic gamma polypeptide, Serine/threonine protein kinase PIK3CG, p120-PI3K, PIK3CG