YWHAB Antibody

YWHAB belongs to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for the gene. Both variants encode the same protein, however, they are differentially expressed in hematopoietic cells.

This YWHAB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-246 amino acids from the C-terminal region of human YWHAB.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Komori, T., et al., Acta Neuropathol. 106 (1) :66-70 (2003) . Cavet, M.E., et al., J. Biol. Chem. 278 (20) :18376-18383 (2003) . Li, Y., et al., J. Biol. Chem. 278 (16) :13663-13671 (2003) . Shumway, S.D., et al., J. Biol. Chem. 278 (4) :2089-2092 (2003) . Parvaresch, S., et al., FEBS Lett. 532 (3) :357-362 (2002) .