YWHAZ Antibody

Product Specifications

Background

YWHAZ belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for the gene. Both variants encode the same protein, however, they are differentially expressed in hematopoietic cells.

NCBI Gene ID

7534

Swiss Prot

P63104

Accession Number

P63104

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This YWHAZ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-93 amino acids from the Central region of human YWHAZ.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

28 kDa

Fragment

Rabbit Ig

Symbol

YWHAZ

NCBI Official Name

14-3-3 protein zeta/delta

NCBI Organism

Homo sapiens

Background Reference 01

Powell, D.W., et al., Mol. Cell. Biol. 23 (15) :5376-5387 (2003) .

Background Reference 02

Zhu, P., et al., Biochem. Biophys. Res. Commun. 301 (4) :991-999 (2003) .

Background Reference 03

Li, Y., et al., J. Biol. Chem. 277 (47) :44593-44596 (2002) .

Background Reference 04

Wang, H., et al., J. Clin. Endocrinol. Metab. 87 (6) :2629-2634 (2002) .

Other Product Names

14-3-3 protein zeta/delta, Protein kinase C inhibitor protein 1, KCIP-1, YWHAZ

Tested Applications

WB, IHC-P, Flow

Protein ID

52000887

Physical Properties

Liquid

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