PCK1 Antibody

Product Specifications

Background

This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. A mitochondrial isozyme of the encoded protein also has been characterized.

NCBI Gene ID

5105

Swiss Prot

P35558

Accession Number

P35558

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This PCK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-70 amino acids from the N-terminal region of human PCK1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

69 kDa

Fragment

Rabbit Ig

Symbol

PCK1

NCBI Official Name

Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

NCBI Organism

Homo sapiens

Background Reference 01

Berger, K. et al. PLoS ONE. 4 (3) : e4671 (2009) .

Background Reference 02

Dunten, P., et al., J. Mol. Biol. 316 (2) :257-264 (2002) .

Background Reference 03

Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26) :16899-16903 (2002) .

Background Reference 04

Deloukas, P., et al., Nature 414 (6866) :865-871 (2001) .

Other Product Names

Phosphoenolpyruvate carboxykinase, cytosolic [GTP], PEPCK-C, PCK1, PEPCK1

Tested Applications

WB, IHC-P

Protein ID

93138710

Physical Properties

Liquid

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