NM23 Antibody

Product Specifications

Background

NME1 was identified because of its reduced mRNA transcript levels in highly metastatic cells. NME1 encodes the 'A' isoform of nucleoside diphosphate kinase (NDK) . NDK exists as a hexamer composed of the 'A' (NME1) and 'B' (encoded by NME2) isoforms. Mutations in NME1 have been identified in aggressive neuroblastomas.

NCBI Gene ID

4830

Swiss Prot

P15531

Accession Number

P15531

Host

Rabbit

Reactivity

Human

Immunogen

This NM23 (NME1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-54 amino acids from the N-terminal region of human NM23 (NME1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

17 kDa

Fragment

Rabbit Ig

Symbol

NME1

NCBI Official Name

Nucleoside diphosphate kinase A

NCBI Organism

Homo sapiens

Background Reference 01

Munier, A., et al., Exp. Cell Res. 289 (2) :295-306 (2003) .

Background Reference 02

Chen, Y., et al., J. Mol. Biol. 332 (4) :915-926 (2003) .

Background Reference 03

Kim, Y.I., et al., Biochem. Biophys. Res. Commun. 307 (2) :281-289 (2003) .

Background Reference 04

Wang, P.H., et al., Gynecol. Obstet. Invest. 55 (1) :14-19 (2003) .

Other Product Names

Nucleoside diphosphate kinase A, NDK A, NDP kinase A, Granzyme A-activated DNase, GAAD, Metastasis inhibition factor nm23, NM23-H1, Tumor metastatic process-associated protein, NME1, NDPKA, NM23