GAK Antibody
Product Specifications
Background
GAK, a member of the Ser/Thr protein kinase family, associates with cyclin G and CDK5. It appears to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. GAK localizes to the perinuclear area and to the trans-Golgi network. It is also observed on the plasma membrane, probably at focals adhesions. Expression is ubiquitous, wiht highest levels in testis. The protein contains 1 J domain and 1 tensin domain.
NCBI Gene ID
2580
Swiss Prot
O14976
Accession Number
O14976
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This GAK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1140-1170 amino acids from the C-terminal region of human GAK.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
143 kDa
Fragment
Rabbit Ig
Symbol
GAK
NCBI Official Name
Cyclin-G-associated kinase
NCBI Organism
Homo sapiens
Background Reference 01
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26) :16899-16903 (2002) .
Background Reference 02
Greener, T., et al., J. Biol. Chem. 275 (2) :1365-1370 (2000) .
Background Reference 03
Kimura, S.H., et al., Genomics 44 (2) :179-187 (1997) .
Other Product Names
Cyclin-G-associated kinase, GAK
Tested Applications
WB, IHC-P
Physical Properties
Liquid
Curated Selection
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