PIP5K2 Alpha Antibody
Product Specifications
Background
Phosphatidylinositol-4,5-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. TPIP5K2A is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. The protein is a member of the phosphatidylinositol-4-phosphate 5-kinase family.
NCBI Gene ID
5305
Swiss Prot
P48426
Accession Number
P48426
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This PIP5K2 Alpha (PIP5K2A) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-139 amino acids from the N-terminal region of human PIP5K2 Alpha (PIP5K2A) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
46 kDa
Fragment
Rabbit Ig
Symbol
PIP4K2A
NCBI Official Name
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
NCBI Organism
Homo sapiens
Background Reference 01
Rozenvayn, N., et al., J. Biol. Chem. 278 (10) :8126-8134 (2003) .
Background Reference 02
Boronenkov, I.V., et al., J. Biol. Chem. 270 (7) :2881-2884 (1995) .
Background Reference 03
Loijens, J.C., et al., Adv. Enzyme Regul. 36, 115-140 (1996) .
Background Reference 04
Divecha, N., et al., Biochem. J. 309 (Pt 3), 715-719 (1995) .
Other Product Names
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha, Diphosphoinositide kinase 2-alpha, PIP5KIII, Phosphatidylinositol 5-phosphate 4-kinase type II alpha, PI (5) P 4-kinase type II alpha, PIP4KII-alpha, PtdIns (4) P-5-kinase B isoform, PtdIns (4) P-5-kinase C isoform, PtdIns (5) P-4-kinase isoform 2-alpha, PIP4K2A, PIP5K2, PIP5K2A
Tested Applications
WB, IHC-P
Protein ID
18266879
Physical Properties
Liquid
Frequently Asked Questions
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