PIP5K2 Alpha Antibody

Product Specifications

Background

Phosphatidylinositol-4,5-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. TPIP5K2A is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. The protein is a member of the phosphatidylinositol-4-phosphate 5-kinase family.

NCBI Gene ID

5305

Swiss Prot

P48426

Accession Number

P48426

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This PIP5K2 Alpha (PIP5K2A) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-139 amino acids from the N-terminal region of human PIP5K2 Alpha (PIP5K2A) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

46 kDa

Fragment

Rabbit Ig

Symbol

PIP4K2A

NCBI Official Name

Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

NCBI Organism

Homo sapiens

Background Reference 01

Rozenvayn, N., et al., J. Biol. Chem. 278 (10) :8126-8134 (2003) .

Background Reference 02

Boronenkov, I.V., et al., J. Biol. Chem. 270 (7) :2881-2884 (1995) .

Background Reference 03

Loijens, J.C., et al., Adv. Enzyme Regul. 36, 115-140 (1996) .

Background Reference 04

Divecha, N., et al., Biochem. J. 309 (Pt 3), 715-719 (1995) .

Other Product Names

Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha, Diphosphoinositide kinase 2-alpha, PIP5KIII, Phosphatidylinositol 5-phosphate 4-kinase type II alpha, PI (5) P 4-kinase type II alpha, PIP4KII-alpha, PtdIns (4) P-5-kinase B isoform, PtdIns (4) P-5-kinase C isoform, PtdIns (5) P-4-kinase isoform 2-alpha, PIP4K2A, PIP5K2, PIP5K2A