PI3KCA Antibody

Product Specifications

Background

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. This protein represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns (4,5) P2. PI3KCA has been found to be oncogenic and has been implicated in cervical cancers.

NCBI Gene ID

5290

Swiss Prot

P42336

Accession Number

P42336

Host

Rabbit

Reactivity

Human

Immunogen

This PI3KCA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1019-1050 amino acids from the C-terminal region of human PI3KCA.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Immunology, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

124 kDa

Fragment

Rabbit Ig

Symbol

PIK3CA

NCBI Official Name

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

NCBI Organism

Homo sapiens

Background Reference 01

Tiwari, S. Nat Immunol. August; 10 (8) : 907?17 (2009) .

Background Reference 02

Ballou, L.M., et al., J. Biol. Chem. 278 (26) :23472-23479 (2003) .

Background Reference 03

Singh, B., et al., Genes Dev. 16 (8) :984-993 (2002) .

Background Reference 04

Shayesteh, L., et al., Nat. Genet. 21 (1) :99-102 (1999) .

Other Product Names

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, PI3-kinase subunit alpha, PI3K-alpha, PI3Kalpha, PtdIns-3-kinase subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha, PtdIns-3-kinase subunit p110-alpha, p110alpha, Phosphoinositide-3-kinase catalytic alpha polypeptide, Serine/threonine protein kinase PIK3CA, PIK3CA