PLK1 Antibody

Product Specifications

Background

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.

NCBI Gene ID

5347

Swiss Prot

P53350

Accession Number

P53350

Host

Rabbit

Reactivity

Human

Immunogen

This PLK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 573-603 amino acids from the C-terminal region of human PLK1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

68 kDa

Fragment

Rabbit Ig

Symbol

PLK1

NCBI Official Name

Serine/threonine-protein kinase PLK1

NCBI Organism

Homo sapiens

Background Reference 01

Ree, A.H., et al., Oncogene 22 (55) :8952-8955 (2003) .

Background Reference 02

Cheng, K.Y., et al., EMBO J. 22 (21) :5757-5768 (2003) .

Background Reference 03

Elia, A.E., et al., Cell 115 (1) :83-95 (2003) .

Background Reference 04

Lin, H.R., et al., J. Biol. Chem. 278 (38) :35979-35987 (2003) .

Other Product Names

Serine/threonine-protein kinase PLK1, Polo-like kinase 1, PLK-1, Serine/threonine-protein kinase 13, STPK13, PLK1, PLK

Tested Applications

WB, IHC-P

Protein ID

1709658

Physical Properties

Liquid

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