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PAK1 Antibody

Product Specifications

Background

PAK1, a member of the STE20 subfamily of Ser/Thr protein kinases, acts on a variety of targets. It is likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. The protein interacts tightly with GTP-bound but not GDP-bound CDC42/P21 and RAC1. PAK1 binds to the caspase-cleaved p110 isoform of CDC2L1 and CDC2L2, p110C, but not the full-length proteins. It is a component of cytoplasmic complexes, which also contain PXN, ARHGEF6 and GIT1. The protein is autophosphorylated when activated by CDC42/p21. Structurally, the PAK1 contains 1 CRIB domain.

NCBI Gene ID

5058

Swiss Prot

Q13153

Accession Number

Q13153

Host

Rabbit

Reactivity

Human

Immunogen

This PAK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-430 amino acids from human PAK1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat, Rabbit, Xenopus

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=63-291

Calculated Molecular Weight

61 kDa

Fragment

Rabbit Ig

Symbol

PAK1

NCBI Official Name

Serine/threonine-protein kinase PAK 1

NCBI Organism

Homo sapiens

Background Reference 01

Chen, S., et al., J. Biol. Chem. 278 (22) :20029-20036 (2003) .

Background Reference 02

Sells, M.A., et al., Curr. Biol. 7 (3) :202-210 (1997) .

Background Reference 03

Brown, J.L., et al., Curr. Biol. 6 (5) :598-605 (1996) .

Other Product Names

Serine/threonine-protein kinase PAK 1, Alpha-PAK, p21-activated kinase 1, PAK-1, p65-PAK, PAK1

Tested Applications

WB, IHC-P, IF

Protein ID

90111767

Physical Properties

Liquid

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