MST1 Antibody

Product Specifications

Background

MST1 is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it is possible that this protein induces the chromatin condensation observed in this process.

NCBI Gene ID

6789

Swiss Prot

Q13043

Accession Number

Q13043

Host

Rabbit

Reactivity

Human

Immunogen

This MST1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 385-415 amino acids from the C-terminal region of human MST1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

56 kDa

Fragment

Rabbit Ig

Symbol

STK4

NCBI Official Name

Serine/threonine-protein kinase 4

NCBI Organism

Homo sapiens

Background Reference 01

Cheung, W.L., et al., Cell 113 (4) :507-517 (2003) .

Background Reference 02

Lin, Y., et al., J. Biol. Chem. 277 (50) :47991-48001 (2002) .

Background Reference 03

De Souza, P.M., et al., Blood 99 (9) :3432-3438 (2002) .

Background Reference 04

Ura, S., et al., Proc. Natl. Acad. Sci. U.S.A. 98 (18) :10148-10153 (2001) .

Other Product Names

Serine/threonine-protein kinase 4, Mammalian STE20-like protein kinase 1, MST-1, STE20-like kinase MST1, Serine/threonine-protein kinase Krs-2, Serine/threonine-protein kinase 4 37kDa subunit, MST1/N, Serine/threonine-protein kinase 4 18kDa subunit, MST1/C, STK4, KRS2, MST1