MLK1 Antibody
Product Specifications
Background
MLK1 is a MLK (MAP3K) type protein kinase. The catalytic domain of mixed-lineage kinases (MLKs) kinases have amino acid sequence similarity to both the tyr-specific and the ser/thr-specific kinase classes. In addition to thee unusual nature of the kinase catalytic domains, MLK1 and MLK2 contain 2 leu/ile-zipper motifs and a basic sequence near their C-termini. MLK1 is a member of the neuronal apoptotic JNK/c-Jun pathway acting between Rac1/Cdc42 and MKK4 and -7 in death signaling. MLK1 expression has been documented in human epithelial tumor cell lines of colonic, breast and esophageal origin.
NCBI Gene ID
4293
Swiss Prot
P80192
Accession Number
P80192
Host
Rabbit
Reactivity
Human
Immunogen
This MLK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1070-1104 amino acids from the C-terminal region of human MLK1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
122 kDa
Fragment
Rabbit Ig
Symbol
MAP3K9
NCBI Official Name
Mitogen-activated protein kinase kinase kinase 9
NCBI Organism
Homo sapiens
Background Reference 01
Durkin, J.T., et al., Biochemistry 43 (51) :16348-16355 (2004) .
Background Reference 02
Gallo, K.A., et al., J. Biol. Chem. 269 (21) :15092-15100 (1994) .
Background Reference 03
Dorow, D.S., et al., Eur. J. Biochem. 213 (2) :701-710 (1993) .
Other Product Names
Mitogen-activated protein kinase kinase kinase 9, Mixed lineage kinase 1, MAP3K9, MLK1, PRKE1
Tested Applications
WB, IHC-P
Protein ID
116242625
Physical Properties
Liquid
Curated Selection
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