CYP2R1 Antibody
Product Specifications
Background
CYP2R1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in CYP2R1 gene has been associated with selective 25-hydroxyvitamin D deficiency.
NCBI Gene ID
120227
Swiss Prot
Q6VVX0
Accession Number
Q6VVX0
Host
Rabbit
Reactivity
Human
Immunogen
This CYP2R1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 464-496 amino acids from the C-terminal region of human CYP2R1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
57 kDa
Fragment
Rabbit Ig
Symbol
CYP2R1
NCBI Official Name
Vitamin D 25-hydroxylase
NCBI Organism
Homo sapiens
Background Reference 01
Ramos-Lopez, E., Diabetes Obes Metab 10 (8), 683-685 (2008)
Background Reference 02
Strushkevich, N., J. Mol. Biol. 380 (1), 95-106 (2008)
Background Reference 03
Ramos-Lopez, E., Diabetes Metab. Res. Rev. 23 (8), 631-636 (2007)
Background Reference 04
Nelson, D.R., Pharmacogenetics 14 (1), 1-18 (2004)
Other Product Names
Vitamin D 25-hydroxylase, Cytochrome P450 2R1, CYP2R1
Tested Applications
WB, IHC-P
Protein ID
62286619
Physical Properties
Liquid
Curated Selection
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