CYP21A2 Antibody
Product Specifications
Background
CYP21A2 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in CYP21A2 gene cause congenital adrenal hyperplasia.
NCBI Gene ID
1589
Swiss Prot
P08686
Accession Number
P08686
Host
Rabbit
Reactivity
Human
Immunogen
This CYP21A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-87 amino acids from the N-terminal region of human CYP21A2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=63-263
Calculated Molecular Weight
56 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CYP21A2
NCBI Official Name
Steroid 21-hydroxylase
NCBI Organism
Homo sapiens
Background Reference 01
Guerra-Junior, G., Clin. Exp. Immunol. 155 (2), 182-188 (2009)
Background Reference 02
Abid, F., Clin. Chem. Lab. Med. 46 (12), 1707-1713 (2008)
Background Reference 03
Nelson, D.R., Pharmacogenetics 14 (1), 1-18 (2004)
Other Product Names
Steroid 21-hydroxylase, 21-OHase, Cytochrome P-450c21, Cytochrome P450 21, Cytochrome P450 XXI, Cytochrome P450-C21, Cytochrome P450-C21B, CYP21A2, CYP21, CYP21B
Tested Applications
WB
Protein ID
117275
Physical Properties
Liquid
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