CYP17A1 Antibody
Product Specifications
Background
CYP17A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in CYP17A1 gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
NCBI Gene ID
1586
Swiss Prot
P05093
Accession Number
P05093
Host
Rabbit
Reactivity
Human
Immunogen
This CYP17A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 358-388 amino acids from the Central region of human CYP17A1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=63-262
Calculated Molecular Weight
57 kDa
Fragment
Rabbit Ig
Symbol
CYP17A1
NCBI Official Name
Steroid 17-alpha-hydroxylase/17,20 lyase
NCBI Organism
Homo sapiens
Background Reference 01
Yuan, X., Cancer Epidemiol. Biomarkers Prev. 17 (12), 3621-3627 (2008)
Background Reference 02
Nelson, D.R., Pharmacogenetics 14 (1), 1-18 (2004)
Background Reference 03
Imai, T., Hum. Genet. 89 (1), 95-96 (1992)
Other Product Names
Steroid 17-alpha-hydroxylase/17,20 lyase, 17-alpha-hydroxyprogesterone aldolase, CYPXVII, Cytochrome P450 17A1, Cytochrome P450-C17, Cytochrome P450c17, Steroid 17-alpha-monooxygenase, CYP17A1, CYP17, S17AH
Tested Applications
WB, IF
Protein ID
117283
Physical Properties
Liquid
Curated Selection
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