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ALDH4A1 Antibody

Product Specifications

Background

ALDH4A1 belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline.

NCBI Gene ID

8659

Swiss Prot

P30038

Accession Number

P30038

Host

Rabbit

Reactivity

Human

Immunogen

This ALDH4A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 533-561 amino acids from the C-terminal region of human ALDH4A1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

62 kDa

Fragment

Rabbit Ig

Symbol

ALDH4A1

NCBI Official Name

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Yoon, K.A., J. Hum. Genet. 49 (3), 134-140 (2004)

Background Reference 02

Geraghty, M.T., Hum. Mol. Genet. (9), 1411-1415 (1998)

Other Product Names

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial, P5C dehydrogenase, Aldehyde dehydrogenase family 4 member A1, L-glutamate gamma-semialdehyde dehydrogenase, ALDH4A1, ALDH4, P5CDH

Tested Applications

WB, IHC-P

Protein ID

62511241

Physical Properties

Liquid

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