ZAP70 Antibody

Product Specifications

Background

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

NCBI Gene ID

7535

Swiss Prot

P43403

Accession Number

P43403

Host

Rabbit

Reactivity

Human

Immunogen

This ZAP70 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 252-282 amino acids from the Central region of human ZAP70.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

70 kDa

Fragment

Rabbit Ig

Symbol

ZAP70

NCBI Official Name

Tyrosine-protein kinase ZAP-70

NCBI Organism

Homo sapiens

Background Reference 01

Kuroyama, H., et al., Biochem. Biophys. Res. Commun. 315 (4) :935-941 (2004) .

Background Reference 02

Yang, Y., et al., Mol. Cell. Biol. 23 (21) :7667-7677 (2003) .

Background Reference 03

Kuhne, M.R., et al., J. Immunol. 171 (2) :860-866 (2003) .

Background Reference 04

Kremer, K.N., et al., J. Immunol. 171 (1) :360-367 (2003) .

Other Product Names

Tyrosine-protein kinase ZAP-70, 70 kDa zeta-chain associated protein, Syk-related tyrosine kinase, ZAP70, SRK

Tested Applications

WB, IHC-P

Protein ID

1177044

Physical Properties

Liquid

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