TGF Beta Receptor I Antibody
Product Specifications
Background
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS) .
NCBI Gene ID
7046
Swiss Prot
P36897
Accession Number
P36897
Host
Rabbit
Reactivity
Human
Immunogen
This TGF Beta Receptor I antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-163 amino acids from the Central region of human TGF Beta Receptor I.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat, Pig, Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=63-218
Calculated Molecular Weight
56 kDa
Fragment
Rabbit Ig
Symbol
TGFBR1
NCBI Official Name
TGF-beta receptor type-1
NCBI Organism
Homo sapiens
Background Reference 01
Itoh, S., et al., J. Biol. Chem. 278 (6) :3751-3761 (2003) . Valcourt, U., et al., J. Biol. Chem. 277 (37) :33545-33558 (2002) . Bourguignon, L.Y., et al., J. Biol. Chem. 277 (42) :39703-39712 (2002) . Jude, E.B., et al., Diabet. Med. 19 (6) :440-447 (2002) . Nagel, D., et al., Biochem. Biophys. Res. Commun. 290 (5) :1558-1563 (2002) .
Other Product Names
TGF-beta receptor type-1, TGFR-1, Activin A receptor type II-like protein kinase of 53kD, Activin receptor-like kinase 5, ALK-5, ALK5, Serine/threonine-protein kinase receptor R4, SKR4, TGF-beta type I receptor, Transforming growth factor-beta receptor type I, TGF-beta receptor type I, TbetaR-I, TGFBR1, ALK5, SKR4
Tested Applications
WB, IHC-P
Protein ID
547777
Physical Properties
Liquid
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