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ACVRL1 Antibody

Product Specifications

Background

ACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. This protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.

NCBI Gene ID

94

Swiss Prot

P37023

Accession Number

P37023

Host

Rabbit

Reactivity

Human

Immunogen

This ACVRL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 474-503 amino acids from the C-terminal region of human ACVRL1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=63-214

Calculated Molecular Weight

56 kDa

Fragment

Rabbit Ig

Symbol

ACVRL1

NCBI Official Name

Serine/threonine-protein kinase receptor R3

NCBI Organism

Homo sapiens

Background Reference 01

Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26) :16899-16903 (2002) .

Background Reference 02

Berg, J.N., et al., Am. J. Hum. Genet. 61 (1) :60-67 (1997) .

Background Reference 03

Johnson, D.W., et al., Nat. Genet. 13 (2) :189-195 (1996) .

Background Reference 04

Ten Dijke, P., et al., Oncogene 8 (10) :2879-2887 (1993) .

Other Product Names

Serine/threonine-protein kinase receptor R3, SKR3, Activin receptor-like kinase 1, ALK-1, TGF-B superfamily receptor type I, TSR-I, ACVRL1, ACVRLK1, ALK1

Tested Applications

WB, IHC-P, Flow

Protein ID

3915750

Physical Properties

Liquid

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