AREG Antibody
Product Specifications
Background
AREG is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha) . This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This protein is associated with a psoriasis-like skin phenotype.
NCBI Gene ID
374
Swiss Prot
P15514
Accession Number
P15514
Host
Rabbit
Reactivity
Human
Immunogen
This AREG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-252 amino acids from the C-terminal region of human AREG.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
28 kDa
Fragment
Rabbit Ig
Symbol
AREG
NCBI Official Name
Amphiregulin
NCBI Organism
Homo sapiens
Background Reference 01
Shim, J.Y., J. Korean Med. Sci. 23 (5), 857-863 (2008)
Background Reference 02
Eckstein, N., J. Biol. Chem. 283 (2), 739-750 (2008)
Background Reference 03
Revillion, F., Ann. Oncol. 19 (1), 73-80 (2008)
Background Reference 04
Kimura, H., Nature 348 (6298), 257-260 (1990)
Other Product Names
Amphiregulin, AR, Colorectum cell-derived growth factor, CRDGF, AREG, SDGF
Tested Applications
WB, IHC-P
Protein ID
113754
Physical Properties
Liquid
Curated Selection
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