SEMA3A Antibody
Product Specifications
Background
SEMA3A is a member of the semaphorin family with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.
NCBI Gene ID
10371
Swiss Prot
Q14563
Accession Number
Q14563
Host
Rabbit
Reactivity
Human
Immunogen
This SEMA3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 535-566 amino acids from the Central region of human SEMA3A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Chicken, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
89 kDa
Fragment
Rabbit Ig
Symbol
SEMA3A
NCBI Official Name
Semaphorin-3A
NCBI Organism
Homo sapiens
Background Reference 01
Narazaki, M., Blood 111 (8), 4126-4136 (2008)
Background Reference 02
Tannemaat, M.R., J. Neurosci. 27 (52), 14260-14264 (2007)
Background Reference 03
Appleton, B.A., EMBO J. 26 (23), 4902-4912 (2007)
Other Product Names
Semaphorin-3A, Semaphorin III, Sema III, SEMA3A, SEMAD
Tested Applications
WB, IHC-P
Protein ID
8134674
Physical Properties
Liquid
Curated Selection
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