SMAD4 Antibody

Product Specifications

Background

SMAD4 is the common SMAD (co-SMAD) mediator of signal transduction by TGF-beta (transforming growth factor) . It promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. It may act as a tumor suppressor.

NCBI Gene ID

4089

Swiss Prot

Q13485

Accession Number

Q13485

Host

Rabbit

Reactivity

Human

Immunogen

This SMAD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-428 amino acids from the C-terminal region of human SMAD4.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Obesity, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

60 kDa

Fragment

Rabbit Ig

Symbol

SMAD4

NCBI Official Name

Mothers against decapentaplegic homolog 4

NCBI Organism

Homo sapiens

Background Reference 01

Sekiya, T., et al., Biochem. Biophys. Res. Commun. 320 (3) :680-684 (2004) .

Background Reference 02

Horvath, L.G., et al., Prostate 59 (3) :234-242 (2004) .

Background Reference 03

Li, L., et al., Mol. Cell. Biol. 24 (2) :856-864 (2004) .

Background Reference 04

Wan, M., et al., J. Biol. Chem. 279 (15) :14484-14487 (2004) .

Other Product Names

Mothers against decapentaplegic homolog 4, MAD homolog 4, Mothers against DPP homolog 4, Deletion target in pancreatic carcinoma 4, SMAD family member 4, SMAD 4, Smad4, hSMAD4, SMAD4, DPC4, MADH4