ARHE Antibody

Product Specifications

Background

Members of the Rho family of Ras-related GTPases, such as ARHE, regulate the organization of the actin cytoskeleton in response to extracellular growth factors. Like Ras (MIM 190020), Rho family members appear to cycle between an inactive GDP-bound form and an active GTP-bound form. Three major regulators of Rho activity have been identified: RhoGDIs, which interact with the GDP-bound Rho proteins to keep them in a resting complex (see MIM 601925) ; GEFs, which promote GDP/GTP exchange leading to activation of Rho proteins (see MIM 601855) ; and GAPs, which stimulate GTP hydrolysis and return the activated Rho protein to its inactive form (see MIM 602680) (Nobes et al., 1998 [PubMed 9531558]) .

NCBI Gene ID

390

Swiss Prot

P61587

Accession Number

P61587

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

This ARHE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-165 amino acids from the Central region of human ARHE.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Pig

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

27 kDa

Fragment

Rabbit Ig

Symbol

RND3

NCBI Official Name

Rho-related GTP-binding protein RhoE

NCBI Organism

Homo sapiens

Background Reference 01

Pinner, S., Nat. Cell Biol. 10 (2), 127-137 (2008)

Background Reference 02

Poch, E., Exp. Cell Res. 313 (4), 719-731 (2007)

Background Reference 03

Ongusaha, P.P., Curr. Biol. 16 (24), 2466-2472 (2006)

Other Product Names

Rho-related GTP-binding protein RhoE, Protein MemB, Rho family GTPase 3, Rho-related GTP-binding protein Rho8, Rnd3, RND3, ARHE, RHO8, RHOE

Tested Applications

WB, IHC-P

Protein ID

47606459

Physical Properties

Liquid

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