PDX1 Antibody
Product Specifications
Background
PDX1 is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. This nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in the gene encoding PDX1 are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4) .
NCBI Gene ID
3651
Swiss Prot
P52945
Accession Number
P52945
Host
Rabbit
Reactivity
Human
Immunogen
This PDX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-69 amino acids from the N-terminal region of human PDX1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=63-176
Calculated Molecular Weight
31 kDa
Fragment
Rabbit Ig
Symbol
PDX1
NCBI Official Name
Pancreas/duodenum homeobox protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Ma, J., Carcinogenesis 29 (7), 1327-1333 (2008)
Background Reference 02
Watada, H., Biochem. Biophys. Res. Commun. 229 (3), 746-751 (1996)
Other Product Names
Pancreas/duodenum homeobox protein 1, PDX-1, Glucose-sensitive factor, GSF, Insulin promoter factor 1, IPF-1, Insulin upstream factor 1, IUF-1, Islet/duodenum homeobox-1, IDX-1, Somatostatin-transactivating factor 1, STF-1, PDX1, IPF1, STF1
Tested Applications
WB, IHC-P
Protein ID
1708540
Physical Properties
Liquid
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