HCK Antibody

Product Specifications

Background

HCK is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq].

NCBI Gene ID

3055

Swiss Prot

P08631

Accession Number

P08631

Host

Rabbit

Reactivity

Human

Immunogen

This HCK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-156 amino acids from the N-terminal region of human HCK.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat, Monkey

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

60 kDa

Fragment

Rabbit Ig

Symbol

HCK

NCBI Official Name

Tyrosine-protein kinase HCK

NCBI Organism

Homo sapiens

Background Reference 01

Hassan, R., et al. J. Cell. Physiol. 221 (2) :458-468 (2009)

Background Reference 02

Kennah, E., et al. Blood 113 (19) :4646-4655 (2009)

Background Reference 03

Voss, M., et al. BMC Immunol. 10, 53 (2009) :

Background Reference 04

Rikova, K., et al. Cell 131 (6) :1190-1203 (2007)

Other Product Names

Tyrosine-protein kinase HCK, Hematopoietic cell kinase, Hemopoietic cell kinase, p59-HCK/p60-HCK, p59Hck, p61Hck, HCK

Tested Applications

WB, IHC-P, Flow

Protein ID

20141296

Physical Properties

Liquid

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