FAK1 Antibody

Product Specifications

Background

FAK1 is a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. This protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of the gene encoding FAK1 may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix.

NCBI Gene ID

5747

Swiss Prot

Q05397

Accession Number

Q05397

Host

Rabbit

Reactivity

Human

Immunogen

This FAK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 557-587 amino acids from human FAK1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Chicken, Mouse, Rat, Xenopus

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

119 kDa

Fragment

Rabbit Ig

Symbol

PTK2

NCBI Official Name

Focal adhesion kinase 1

NCBI Organism

Homo sapiens

Background Reference 01

Okamoto, H., et al., Hepatology 38 (5) :1242-1249 (2003) .

Background Reference 02

Moritake, H., et al., Cancer Genet. Cytogenet. 146 (2) :102-109 (2003) .

Background Reference 03

Liu, X.W., et al., J. Biol. Chem. 278 (41) :40364-40372 (2003) .

Background Reference 04

Avraham, H.K., et al., J. Biol. Chem. 278 (38) :36661-36668 (2003) .

Other Product Names

Focal adhesion kinase 1, FADK 1, Focal adhesion kinase-related nonkinase, FRNK, Protein phosphatase 1 regulatory subunit 71, PPP1R71, Protein-tyrosine kinase 2, p125FAK, pp125FAK, PTK2, FAK, FAK1