TRKA Antibody

Product Specifications

Background

TRKA (also known as NTRK1) is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in the TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.

NCBI Gene ID

4914

Swiss Prot

P04629

Accession Number

P04629

Host

Rabbit

Reactivity

Human

Immunogen

This TRKA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 654-683 amino acids from the Central region of human TRKA.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Cell Cycle, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Chicken, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

87 kDa

Fragment

Rabbit Ig

Symbol

NTRK1

NCBI Official Name

High affinity nerve growth factor receptor

NCBI Organism

Homo sapiens

Background Reference 01

Tokusashi, Y., et al., Int. J. Cancer 114 (1) :39-45 (2005) .

Background Reference 02

Schulte, J.H., et al., Oncogene 24 (1) :165-177 (2005) .

Background Reference 03

Frattini, M., et al., Oncogene 23 (44) :7436-7440 (2004) .

Background Reference 04

Tacconelli, A., et al., Cancer Cell 6 (4) :347-360 (2004) .

Other Product Names

High affinity nerve growth factor receptor, Neurotrophic tyrosine kinase receptor type 1, TRK1-transforming tyrosine kinase protein, Tropomyosin-related kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A, Trk-A, gp140trk, p140-TrkA, NTRK1, MTC, TRK, TRKA