RET Antibody

Product Specifications

Background

RET, a member of the cadherin superfamily, is one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This protein plays a crucial role in neural crest development, and the gene can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations i are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma.

NCBI Gene ID

5979

Swiss Prot

P07949

Accession Number

P07949

Host

Rabbit

Reactivity

Human

Immunogen

This RET antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-44 amino acids from the N-terminal region of human RET.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

124 kDa

Fragment

Rabbit Ig

Symbol

RET

NCBI Official Name

Proto-oncogene tyrosine-protein kinase receptor Ret

NCBI Organism

Homo sapiens

Background Reference 01

Da Silva, A.M., et al., J. Clin. Endocrinol. Metab. 88 (11) :5438-5443 (2003) .

Background Reference 02

McWhinney, S.R., et al., J. Clin. Endocrinol. Metab. 88 (10) :4911-4916 (2003) .

Background Reference 03

D'Alessio, A., et al., Endocrinology 144 (10) :4298-4305 (2003) .

Background Reference 04

Soares, P., et al., Oncogene 22 (29) :4578-4580 (2003) .

Other Product Names

Proto-oncogene tyrosine-protein kinase receptor Ret, Cadherin family member 12, Proto-oncogene c-Ret, Soluble RET kinase fragment, Extracellular cell-membrane anchored RET cadherin 120 kDa fragment, RET, CDHF12, CDHR16, PTC, RET51